POS-742 LONG TERM OUTCOMES OF POST-TRANSPLANT INFECTIONS IN ADULT RENAL TRANSPLANT RECIPIENTS

Infections are a major cause of morbidity in the form graft loss and mortality renal transplant recipients (RTR). A number factors pre peri period increase susceptibility to post-transplant infections (PTI) affecting overall patient survival. An observational study 644 adult RTR (=>18yrs) between Jan 2010 Dec 2015, followed till Jun 2019. Primary objective was epidemiology risk PTI. Secondary evaluate outcomes. PTI were seen 83.1%, which majority (64%) occurred first year. Of all infections, 55.5% bacterial, 18.5% viral, 10.8% parasitic, 8% fungal, remaining 7.1% mycobacterial. UTI (37.4%) most common infection with E. Coli (18.9%) being commonest cause. Relative for dysfunction 4 times higher (95%CI 3.5-6.6, p<0.01), 3 1.4-6.1p<0.01) death 1.3-8.1, p=0.01) as compared non Recurrence had 2 1.2-3.1, p<0.01) (95% CI 1.9-5.0, p=0.00). Overall, 19.1% rate 12.1% population. The relative fungal other 1.23-2.18, p<0.003). than 1.20-2.56, p <0.008) On multivariate analysis, predictors ATG induction (P<0.01), Tuberculosis (P=0.02) dialysis vintage (P=0.02). KM survival inferior at 1,5and 9years; (graft: 94.6%;81.7%;70.3% vs 98%; 92.2%; 90%, p=0.004, patient: 97.9%;88.2%;81.9% 98.3%; 95.2%; 92.9%, p=0.012) have significant impact on (70% 90%) (82% 93%) RTR, having worse